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Computed tomography-guided cutting needle biopsy for lung nodules: A comparative study between low-dose and standard
Hui-Mei Zhang1, Xiao-Bing Huo1, Hua-Long Wang1
1Department of Radiology, Binzhou People's Hospital, Binzhou, No. 661 No. 7 Huanghe Road, Binzhou.
Medicine
|February 6, 2021
Summary
Low-dose computed tomography (CT)-guided cutting needle biopsy (CNB) for lung nodules offers comparable diagnostic accuracy and safety to standard-dose CT-guided CNB. This low-dose approach significantly reduces radiation exposure for patients undergoing lung nodule biopsies.
Area of Science:
- Radiology
- Pulmonology
- Oncology
Background:
- Computed tomography (CT)-guided cutting needle biopsy (CNB) is a common procedure for diagnosing lung nodules.
- Concerns exist regarding radiation exposure associated with standard-dose CT protocols.
- Evaluating lower-dose protocols is crucial for patient safety and minimizing cumulative radiation.
Purpose of the Study:
- To compare the diagnostic accuracy, safety, and radiation dose of low-dose versus standard-dose CT-guided CNB for lung nodules.
- To determine if a low-dose protocol can achieve similar diagnostic outcomes with reduced radiation exposure.
Main Methods:
- A retrospective study included patients undergoing either low-dose or standard-dose CT-guided CNB for lung nodules between January 2016 and August 2017.
- Diagnostic accuracy (sensitivity, specificity, overall accuracy), complication rates (pneumothorax, hemoptysis), and radiation dose (dose-length product, effective dose) were compared between the two groups.
- Technical success rates were assessed for both protocols.
Main Results:
- Technical success rates were 100% in both low-dose and standard-dose groups.
- Diagnostic accuracy was high in both groups (98.5% for low-dose vs. 94.2% for standard-dose), with no statistically significant difference (P = .380).
- Low-dose CT-guided CNB resulted in a significant reduction in radiation dose (mean effective dose 0.5 mSv vs. 5.3 mSv; P < .001) with comparable rates of pneumothorax and hemoptysis.
Conclusions:
- Low-dose CT-guided CNB is a safe and effective alternative to standard-dose CT-guided CNB for lung nodules.
- The low-dose protocol significantly decreases radiation exposure without compromising diagnostic accuracy or safety.
- This approach represents an important advancement in optimizing radiation safety during lung nodule biopsies.
