Related Experiment Video
Updated: Nov 18, 2025
A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice
Published on: July 20, 2022
Analysis of risk factors and construction of prediction model of drop out from peritoneal dialysis
Li Li1,2, Hualian Pei3, Zhenhui Liu4
1Department of Nephrology.
Insights
Higher education, diabetes, hypertension, and complications like peritonitis increase peritoneal dialysis dropout risk. More hospitalizations after catheterization may protect against discontinuation.
Area of Science:
- Nephrology
- Public Health
Background:
- Peritoneal dialysis (PD) is a crucial renal replacement therapy.
- Understanding dropout factors is vital for patient management and therapy longevity.
Purpose of the Study:
- To identify independent risk factors associated with discontinuation of peritoneal dialysis.
- To develop a predictive model for PD dropout.
Main Methods:
- Retrospective analysis of 377 patients undergoing PD catheterization from 2009-2019.
- Kaplan-Meier survival analysis and multivariate Cox proportional hazards modeling.
- Nomogram construction for dropout probability prediction.
Main Results:
- The overall PD dropout rate was 41.38%.
- Independent risk factors for dropout included higher education level, diabetes, hypertension, repeated peritonitis, and repeated chest complications.
- Increased hospitalizations post-catheterization showed a protective effect (HR: 0.94).
- The prediction model achieved a C-index of 0.74.
Conclusions:
- Higher education, diabetes, hypertension, and recurrent complications are significant risk factors for PD cessation.
- Frequent hospitalizations after PD catheterization may indicate better PD maintenance.
- The developed nomogram offers a tool for predicting PD dropout probability.
Abstract:
This study is to investigate the risk factors for the drop out from peritoneal dialysis.We retrospectively analyzed patients who underwent catheterization between January 1, 2009 and September 30, 2019. The follow-up period ended on November 30, 2019. End point events were the cessation of peritoneal dialysis, including death, conversion to hemodialysis, and kidney transplantation. Kaplan-Meier method was used to analyze peritoneal dialysis curve. Significant factors were included in the multivariate Cox proportional hazards model. Calibration curve was plotted.A total of 377 patients were included in this study. The dropout rate of peritoneal dialysis was 41.38%. The main drop out reason was conversion to hemodialysis, accounting for 41.67% of the total number of drop out, followed by kidney transplantation (28.21%) and death (25%). According to multivariable Cox proportional hazards model analysis, the medium education level (hazard ratio (HR): 2.53, 95% confidence interval (CI): 1.08-5.91, P = .03), high education level (HR: 2.47, 95% CI: 1.03-5.93, P = .04), diabetes (HR: 1.87, 95% CI: 1.24-2.83, P < .03), hypertension (HR: 2.40, 95% CI: 1.64-3.51, P < .01), repeated peritonitis (HR: 5.18, 95% CI: 3.04-8.80, P < .01), and repeated chest complications (HR: 4.98, 95% CI: 2.79-8.89, P < .01) were independent risk factors for dropping out from peritoneal dialysis, while the number of hospitalizations after catheterization (HR: 0.94, 95% CI: 0.89-0.98, P = .01) was protective factor for maintenance of peritoneal dialysis. The C index of the prediction model was 0.74.Higher education level, diabetes, hypertension, repeated peritonitis, and repeated chest complications were the risk factors of dropping out from peritoneal dialysis, while higher number of hospitalizations after catheterization was a protective factor for the maintenance of peritoneal dialysis. The nomogram could predict the probability of dropping out from peritoneal dialysis.
More Related Videos
07:11Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
Published on: July 19, 2018
05:16Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Related Concept Videos
01:25Peritoneal Dialysis II: Peritoneal Dialysis Systems and Complications
01:25Peritoneal Dialysis III: Nursing Management
01:30Peritoneal Dialysis I: Introduction and Procedure
01:25Chronic Kidney Disease I: Introduction
01:30Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
01:27Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...