Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menopause01:28

Menopause

3.4K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
3.4K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.7K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.7K
Infertility in Males01:23

Infertility in Males

413
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
413
Spermatogenesis01:41

Spermatogenesis

107.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
107.5K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

144
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
144
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

187
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
187

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative efficacy of EMLA cream, lidocaine spray, and benzocaine condoms in treating lifelong premature ejaculation: a randomized clinical study.

World journal of urology·2025
Same author

[Multicentric Screening of Local Antibiotic Resistance in Uncomplicated Urinary System Infections: 1850 Patients from 37 Centers].

Mikrobiyoloji bulteni·2025
Same author

Targeting the PANoptosome Using Necrostatin-1 Reduces PANoptosis and Protects the Kidney Against Ischemia-Reperfusion Injury in a Rat Model of Controlled Experimental Nonheart-Beating Donor.

Transplantation proceedings·2024
Same author

Renal Access in Pediatric Supine Miniaturized Percutaneous Nephrolithotomy: Comparative Evaluation of Ultrasound-Fluoroscopy Combined and Biplanar (0°-90°) Fluoroscopic Techniques.

Journal of endourology·2024
Same author

Evening type negatively affects semen quality by deteriorating sperm morphology: Results from an infertility clinic.

European journal of obstetrics, gynecology, and reproductive biology·2024
Same author

Digitalization and Urological Diseases: Severity of Cyberchondria and Level of Health Anxiety in Patients Visiting Outpatient Urology Clinics.

Cyberpsychology, behavior and social networking·2022

Related Experiment Video

Updated: Nov 18, 2025

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

3.0K

At What Age Threshold does the Decline in Semen Parameters Begin?

Mehmet Kutlu Demirkol1, Osman Barut1, Neslihan Temiz Dogan2

  • 1Department of Urology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|February 6, 2021
PubMed
Summary

Male infertility is linked to age, with significant declines in sperm motility, morphology, and vitality observed starting at age 35. Paternal age is a crucial factor for men considering delayed fatherhood.

More Related Videos

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen
04:36

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

Published on: January 19, 2024

4.9K
Sperm Collection of Differential Quality Using Density Gradient Centrifugation
03:28

Sperm Collection of Differential Quality Using Density Gradient Centrifugation

Published on: November 29, 2018

20.2K

Related Experiment Videos

Last Updated: Nov 18, 2025

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

3.0K
Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen
04:36

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

Published on: January 19, 2024

4.9K
Sperm Collection of Differential Quality Using Density Gradient Centrifugation
03:28

Sperm Collection of Differential Quality Using Density Gradient Centrifugation

Published on: November 29, 2018

20.2K

Area of Science:

  • Reproductive Medicine
  • Andrology
  • Human Reproduction

Background:

  • Paternal age is an increasingly recognized factor in male infertility.
  • Understanding age-related changes in semen quality is crucial for reproductive counseling.

Purpose of the Study:

  • To analyze changes in semen parameters across different age groups in infertile men.
  • To determine the age threshold at which semen quality significantly declines.

Main Methods:

  • Retrospective analysis of semen analysis records from 500 infertile men.
  • Patients were categorized into age groups (20-29, 30-34, 35-39, 40-44, 45-55).
  • One-way ANOVA and linear contrast analysis were used to assess age-related differences.

Main Results:

  • No significant linear relationship was found between age and semen volume, concentration, or total sperm count.
  • A significant linear decline was observed in progressive sperm motility, vitality, and morphology with advancing age (p<0.001).
  • Declines in motility, morphology, and vitality began and continued from the 35-39 age group.

Conclusions:

  • Advancing paternal age leads to a significant linear decrease in sperm motility, morphology, and vitality in infertile men.
  • These declines become statistically significant from age 35 onwards.
  • Men considering delayed fatherhood should be aware of the impact of age on fertility.