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The cancer metabolic reprogramming and immune response
Longzheng Xia1, Linda Oyang1, Jinguan Lin1
1Hunan Key Laboratory of Cancer Metabolism, The Affiliated Cancer Hospital of Xiangya School of Medicine, Hunan Cancer Hospital, Central South University, 283 Tongzipo Road, 410013, Changsha, Hunan, China.
Molecular Cancer
|February 6, 2021
Summary
Cancer and immune cell metabolic reprogramming impacts antitumor immunity. Targeting these metabolic pathways offers novel strategies for enhancing cancer immunotherapy effectiveness.
Area of Science:
- Immunology
- Cancer Biology
- Metabolic Pathways
Background:
- Metabolic reprogramming in cancer cells is crucial for tumorigenesis and survival.
- Cancer metabolism influences antitumor immune responses via metabolite release and immune molecule expression.
- Immune cells also undergo metabolic reprogramming essential for their function and homeostasis.
Purpose of the Study:
- To elucidate the regulatory roles of metabolic reprogramming in both cancer and immune cells on antitumor immunity.
- To explore therapeutic strategies targeting metabolic pathways for improved anticancer immunotherapy.
Main Methods:
- Review of current literature on cancer and immune cell metabolism.
- Analysis of metabolic interplay within the tumor microenvironment.
- Discussion of potential therapeutic interventions and combination treatments.
Main Results:
- Metabolic competition between cancer and immune cells creates an acidic tumor microenvironment, impairing immune function.
- Metabolic reprogramming is vital for immune cell proliferation, differentiation, and effector functions.
- Targeting metabolic pathways presents a promising avenue for augmenting immunotherapy.
Conclusions:
- Understanding the metabolic crosstalk between cancer and immune cells is key to overcoming treatment resistance.
- Combining immunotherapy with metabolic interventions holds potential for synergistic anticancer effects.
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