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Cranial aseptic osteomyelitis associated with pyoderma gangrenosum
Enric Piqué-Durán1, Jesús Morera Molina2, Miguel Ángel Limeres-González3
1Sección de Dermatología, Hospital Dr. José Molina Orosa, Lanzarote, Provincia de Las Palmas, España.
Neurocirugia (English Edition)
|February 6, 2021
Summary
Neutrophilic dermatoses rarely affect bone. This case highlights osteomyelitis and pyoderma gangrenosum in an adult, successfully treated with prednisone, emphasizing rare adult bone involvement.
Area of Science:
- Dermatology
- Rheumatology
- Oncology
Background:
- Neutrophilic dermatoses are a diverse group of inflammatory skin conditions.
- These conditions can uncommonly manifest as aseptic neutrophilic abscesses in non-cutaneous tissues.
- Bone involvement secondary to neutrophilic dermatoses is rare, particularly in adults.
Observation:
- A 34-year-old female presented with intractable headaches.
- Imaging revealed an osteolytic lesion in the parietal bone, diagnosed as osteomyelitis.
- Subsequently, she developed pyoderma gangrenosum on both legs.
Findings:
- The patient's symptoms resolved with oral prednisone treatment.
- This case represents a rare instance of adult bone involvement secondary to neutrophilic dermatoses.
- It adds to the limited literature on adult CRMO and its association with pyoderma gangrenosum.
Implications:
- Highlights the potential for systemic and skeletal manifestations of neutrophilic dermatoses in adults.
- Emphasizes the importance of considering osteomyelitis in adults with neutrophilic dermatoses and bone lesions.
- Suggests that early diagnosis and management of neutrophilic dermatoses may prevent severe complications like bone destruction.
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