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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

Updated: Nov 18, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Iodine allergy: Common misperceptions.

Nicole R Wulf1, John Schmitz2, Amy Choi3

  • 1First Databank, South San Francisco, CA, USA.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|February 6, 2021
PubMed
Summary
This summary is machine-generated.

Patients reporting "iodine allergy" may not be allergic to iodine itself. Current evidence suggests iodine is not the allergen in reactions to iodine-containing substances like contrast media.

Keywords:
3-iodobenzylguanidineamiodaronecontrast mediaiodinepovidone-iodine

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Area of Science:

  • Allergy and Immunology
  • Radiology
  • Pharmacology

Background:

  • Iodine is vital for thyroid hormone synthesis.
  • Adverse reactions to iodine-containing substances are often mislabeled as
  • iodine allergy
  • leading to unnecessary avoidance of critical medical treatments.
  • Iodinated contrast media (ICM) are essential diagnostic tools.

Purpose of the Study:

  • To review the current evidence on iodine-containing compounds and alleged iodine allergy cross-reactivity.
  • To evaluate the scientific basis for
  • iodine allergy
  • labeling.

Main Methods:

  • A comprehensive literature review was conducted.
  • 81 relevant articles were included after screening 447 potential sources.
  • Evidence regarding iodine-containing drugs and contrast media was analyzed.

Main Results:

  • Iodine itself has not been identified as the allergen responsible for hypersensitivity reactions to iodinated contrast media, amiodarone, or povidone-iodine.
  • The review found no evidence to support cross-reactivity between various iodine-containing compounds in individuals with reported
  • iodine allergy
  • .

Conclusions:

  • The concept of
  • iodine allergy
  • as a cross-reactive phenomenon is not supported by current scientific evidence.
  • Further investigation is needed to accurately diagnose and manage adverse reactions to iodine-containing substances.