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Updated: Nov 18, 2025

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
miR-3178 as a prognostic indicator and tumor suppressor of gastric cancer
Jin-Cheng Wu1, Zhao-Hui Liu1, Xiaomei Ding2
1Department of General Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, 361001, Fujian, China.
Background:
Gastric cancer is a common malignant tumor with an increasing death rate. MicroRNA can serve as a promising biomarker for the progression and prognosis of various cancers.
Aims:
The clinical significance and biological function of miR-3178 in gastric cancer was assessed in this study.
Methods:
A total of 117 paired tissues were collected from gastric cancer patients. Quantitative real-time polymerase chain reaction was used to detect the expression of miR-3178 in gastric cancer tissues and cells. The association between miR-3178 expression and the clinicopathological features of patients were analyzed by χ2 test. Kaplan-Meier analysis and Cox regression were employed to investigate the prognostic value of miR-3178. Finally, the effect of miR-3178 on the cellular process of gastric cancer was investigated by CCK-8 and transwell assay.
Results:
miR-3178 was downregulated in gastric cancer tissues and cells, which showed a significant association with the TNM stage and lymph node metastasis of patients and a poor prognosis. MiR-3178 and TNM stage were considered as two independent prognostic factors for gastric cancer. Furthermore, the downregulation of miR-3178 promoted cell proliferation, migration, and invasion of gastric cancer by regulating Notch1.
Conclusion:
miR-3178 may be involved in the progression of gastric cancer, which provides new insights into the treatment of gastric cancer.
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