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Related Concept Videos

Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Accelerated white matter lesion analysis based on simultaneous and quantification using magnetic resonance

Ingo Hermann1,2, Eloy Martínez-Heras3, Benedikt Rieger1

  • 1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Magnetic Resonance in Medicine
|February 6, 2021
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Deep learning accelerates magnetic resonance fingerprinting (MRF) for quantitative mapping of T1 and T2 values. This novel pipeline significantly reduces processing time for assessing white matter lesions in multiple sclerosis patients.

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deep learning reconstructionmagnetic resonance fingerprinting

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Area of Science:

  • Medical Imaging
  • Artificial Intelligence
  • Neuroscience

Background:

  • Quantitative magnetic resonance fingerprinting (MRF) offers robust T1 and T2 mapping.
  • Traditional MRF postprocessing is time-consuming, limiting clinical application.
  • Accurate assessment of white matter lesions is crucial for multiple sclerosis (MS) management.

Purpose of the Study:

  • To develop an accelerated postprocessing pipeline for quantitative MRF.
  • To enhance the efficiency and reproducibility of white matter lesion assessment.
  • To integrate deep learning with MRF for faster parametric mapping.

Main Methods:

  • Acquired whole-brain MRF data (EPI scans) with varying TR/TE in 50 MS patients and 10 controls.
  • Applied distortion correction and denoising to MRF T1 and T2 parametric maps.
  • Trained a convolutional neural network (CNN) to reconstruct parametric maps and tissue probability maps.

Main Results:

  • Deep learning reduced postprocessing time from hours to seconds.
  • High accuracy, reliability, and precision were maintained.
  • Mean absolute error (5.6% deviation) and log-cosh loss (6.0% deviation) optimized T1 and T2 reconstruction, respectively.

Conclusions:

  • MRF is a fast and robust tool for quantitative T1 and T2 mapping.
  • Deep learning significantly accelerates MRF reconstruction and postprocessing.
  • This approach facilitates efficient and reproducible white matter lesion assessment.