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DBA/1 mice display equivalent cardiac function to C57BL/6J mice
Zhen Wang1, Zhengwei Zhou1, Paipai Guo1
1Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Hefei, China.
Experimental Physiology
|February 6, 2021
Summary
Normal DBA/1 mice exhibit cardiac function comparable to C57BL/6J mice. This finding supports using DBA/1 mice for studying autoimmune disease-induced cardiac dysfunction.
Area of Science:
- Cardiovascular research
- Immunology
- Animal models
Background:
- Cardiovascular diseases are a growing concern, with autoimmune conditions contributing significantly.
- C57BL/6J mice are commonly used but have low incidence of immune diseases like rheumatoid arthritis.
- DBA/1 mice are more susceptible to certain autoimmune diseases, making them a relevant model.
Purpose of the Study:
- To compare cardiac function and structure between normal adult DBA/1 and C57BL/6J mice.
- To determine if DBA/1 mice are a suitable model for studying autoimmune-related cardiac dysfunction.
Main Methods:
- Monthly echocardiography to monitor cardiac function over six months.
- Isoproterenol challenge to assess cardiac systolic function.
- Western blotting for excitation-contraction coupling proteins and histological analysis of heart tissue.
Main Results:
- No significant differences in systolic or diastolic cardiac function between DBA/1 and C57BL/6J mice.
- Identical heart appearance and structure in both strains.
- DBA/1 mice demonstrated a comparable cardiac beta-adrenergic response to C57BL/6J mice.
Conclusions:
- Normal adult DBA/1 mice possess cardiac function and structure equivalent to C57BL/6J mice.
- DBA/1 mice are a suitable model for investigating cardiac dysfunction in autoimmune diseases.
- This strain facilitates research into potential interventions for autoimmune-related cardiovascular damage.
