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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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siRNA - Small Interfering RNAs02:30

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Long non-coding RNA: An immune cells perspective.

Salman Khan1, Mohammad Masood1, Harshita Gaur2

  • 1Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.

Life Sciences
|February 6, 2021
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) regulate gene expression and immune cell function. Understanding lncRNA roles in immunity offers potential therapeutic targets for diseases.

Keywords:
Gene regulationImmune cellsImmune responseLong non-coding RNAPolarization

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Area of Science:

  • Molecular Biology
  • Immunology
  • Genomics

Background:

  • Long non-coding RNAs (lncRNAs) were initially dismissed as genetic waste.
  • Modern genomics revealed lncRNAs (>200 nucleotides) are crucial gene expression regulators.
  • Emerging evidence links lncRNA expression to immune responses and disease progression.

Purpose of the Study:

  • To review the role of lncRNAs in shaping the function of various immune cells.
  • To explore lncRNA involvement in immune cell responses during disease states.
  • To highlight the potential of lncRNAs as therapeutic targets in immune-related diseases.

Main Methods:

  • Literature review focusing on lncRNA expression and function in immunity.
  • Analysis of studies investigating lncRNAs in macrophages, dendritic cells, NK cells, T cells, B cells, eosinophils, neutrophils, and microglial cells.
  • Synthesis of current knowledge on lncRNA mechanisms in innate and adaptive immunity.

Main Results:

  • lncRNAs differentially expressed across various immune cell types.
  • lncRNAs identified as key regulators in both innate and adaptive immune responses.
  • Evidence suggests lncRNAs influence immune cell function and disease pathogenesis.

Conclusions:

  • lncRNAs play significant roles in immune cell function and immune system regulation.
  • Further research into lncRNA molecular mechanisms is crucial for developing novel therapeutic strategies.
  • Understanding lncRNA relevance to the immune system is imperative for disease treatment.