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Updated: Nov 18, 2025

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
Published on: June 6, 2025
Current challenges for hypertension management: From better hypertension diagnosis to improved patients' adherence
Gianfranco Parati1, Carolina Lombardi1, Martino Pengo2
1Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, S.Luca Hospital, Milan, Italy; Department of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy.
Insights
Improving hypertension control requires better patient identification and treatment strategies. Utilizing advanced blood pressure monitoring and simplified medication regimens can enhance management for better health outcomes.
Area of Science:
- Cardiovascular Medicine
- Public Health
- Clinical Hypertension Management
Background:
- Hypertension control remains a significant global public health challenge, despite advancements in measurement and pharmacotherapy.
- A substantial number of patients with hypertension are undiagnosed or inadequately treated, contributing to disease burden and disability worldwide.
- Current management strategies face challenges in accurate diagnosis and achieving sustained blood pressure control.
Purpose of the Study:
- To address current challenges in hypertension management.
- To explore strategies for improving the identification of sustained blood pressure elevation and specific hypertension phenotypes.
- To enhance blood pressure control achievement in treated patients through optimized treatment regimens and increased patient/physician engagement.
Main Methods:
- Utilizing combined office and out-of-office blood pressure monitoring techniques for improved diagnosis.
- Optimizing and simplifying medication regimens, including drug selection and titration, for consistent 24-hour blood pressure control.
- Leveraging blood pressure telemonitoring and mobile health technologies to promote active patient and physician involvement.
Main Results:
- The paper discusses methods to improve the identification of sustained blood pressure elevation and phenotypes like white coat and masked hypertension.
- Strategies for optimizing antihypertensive medication regimens are presented to achieve better 24-hour blood pressure control.
- The role of telemonitoring and mobile health in enhancing patient and physician engagement in hypertension management is highlighted.
Conclusions:
- Improved diagnostic accuracy through advanced monitoring techniques is crucial for effective hypertension management.
- Simplified and optimized pharmacotherapy, alongside active patient and physician involvement, is key to achieving better blood pressure control.
- Integrating technology like telemonitoring offers a promising avenue for enhancing hypertension care and patient outcomes.
Abstract:
Hypertension control still remains a largely unmet challenge for public health systems. Despite the progress in blood pressure (BP) measurement techniques, and the availability of effective and safe antihypertensive drugs, a large number of hypertensive patients are not properly identified, and a significant proportion of those who receive antihypertensive treatment fail to achieve satisfactory control of their BP levels. It is thus not surprising that hypertension is still a major contributor to disease burden and disability worlwide, even in developed countries. This paper will address current challenges in hypertension management and potential strategies for an improvement in this field. In its first part relevant issues related to hypertension diagnosis will be addressed, in particular how to improve identification of sustained BP elevation and specific BP phenotypes such as white coat and masked hypertension trough the combined use of office and out-of-office BP monitoring techniques. In its second part focus will be on how to improve achievement of hypertension control in treated patients by optimization and simplification of medication regimens, including more efficient selection and titration of antihypertensive drugs and their combinations, aimed at achieving a more consistent 24hBP control; and by favoring a more active patients' and physicians' involvement in hypertension management also through BP telemonitoring and mobile health technologies.
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