Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa
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View abstract on PubMed
Summary
This summary is machine-generated.Tunnels in hidradenitis suppurativa (HS) are immunologically active, contributing to inflammation. Treatment with brodalumab, an IL-17RA antagonist, reduced tunnel size and drainage, suggesting tunnels are a key source of HS inflammation.
Area Of Science
- Dermatology
- Immunology
- Inflammatory Diseases
Background
- Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory condition.
- HS is characterized by nodules, abscesses, and progressing to draining tunnels.
- The role of HS tunnels in disease activity remains unclear.
Purpose Of The Study
- To investigate if HS tunnels are immunologically active.
- To determine the molecular and cellular characteristics of HS tunnels.
- To assess the impact of brodalumab treatment on HS tunnels.
Main Methods
- Ultrasound-guided skin biopsies from HS patients (untreated and brodalumab-treated).
- Immunohistochemistry to analyze tunnel morphology and molecular markers.
- Microdissection of tunnels for cytokine analysis.
- Hierarchical clustering to differentiate HS samples.
Main Results
- HS tunnels mimic psoriasiform epidermal hyperplasia with molecular inflammation (S100A7+).
- Tunnels show increased immune cell infiltration (T cells, dendritic cells, neutrophils) and neutrophil extracellular traps.
- Tunnels exhibit higher levels of epithelium-derived inflammatory cytokines compared to epidermis and healthy controls.
- Brodalumab treatment decreased tunnel size and drainage.
Conclusions
- HS tunnels are a significant source of inflammation in the disease.
- Tunnels possess distinct molecular and cellular inflammatory signatures.
- Targeting IL-17RA with brodalumab may modulate tunnel activity in HS.
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