Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

3.2K
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
3.2K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.6K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.6K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.6K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.6K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

3.8K
Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
3.8K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.1K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.1K
Classification of Leukocytes01:30

Classification of Leukocytes

4.3K
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol.

Nature communications·2019
Same author

Efficient photoelectrochemical water-splitting over carbon membrane linked Au and TiO<sub>2</sub> nanotube arrays film based on multiple carriers transport paths.

Nanotechnology·2019
Same author

HEV-LF<sub>S</sub> : A novel scoring model for patients with hepatitis E virus-related liver failure.

Journal of viral hepatitis·2019
Same author

ACAP1 assembles into an unusual protein lattice for membrane deformation through multiple stages.

PLoS computational biology·2019
Same author

Characterizing the metabolites and the microbial communities of the soy sauce mash affected by temperature and hydrostatic pressure.

Food research international (Ottawa, Ont.)·2019
Same author

4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.

Cell death & disease·2019

Related Experiment Video

Updated: Nov 18, 2025

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.6K

CD300a and CD300f molecules regulate the function of leukocytes.

Yue Cao1, Tianrang Ao2, Xiaohong Wang1

  • 1Department of Tissue Engineering, School of Fundamental Science, China Medical University, Shenyang, Liaoning 110122, China.

International Immunopharmacology
|February 6, 2021
PubMed
Summary

The CD300a and CD300f inhibitory receptors regulate leukocyte functions crucial for immunity. Understanding their expression and regulatory mechanisms offers potential therapeutic targets for inflammatory and infectious diseases.

Keywords:
CD300aCD300fImmunityInflammatory diseaseLeukocyte

More Related Videos

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
11:48

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

11.8K
High-Dimensionality Flow Cytometry for Immune Function Analysis of Dissected Implant Tissues
08:21

High-Dimensionality Flow Cytometry for Immune Function Analysis of Dissected Implant Tissues

Published on: September 15, 2021

2.5K

Related Experiment Videos

Last Updated: Nov 18, 2025

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
12:55

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

3.6K
Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes
11:48

Isolation Protocol of Mouse Monocyte-derived Dendritic Cells and Their Subsequent In Vitro Activation with Tumor Immune Complexes

Published on: May 31, 2018

11.8K
High-Dimensionality Flow Cytometry for Immune Function Analysis of Dissected Implant Tissues
08:21

High-Dimensionality Flow Cytometry for Immune Function Analysis of Dissected Implant Tissues

Published on: September 15, 2021

2.5K

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • The CD300 molecule family comprises type I transmembrane glycoproteins found on mammalian cell membranes.
  • Among the eight members, CD300a and CD300f are identified as inhibitory receptors.
  • These receptors play significant roles in modulating leukocyte functions.

Purpose of the Study:

  • To review the expression patterns of CD300a and CD300f on leukocytes.
  • To elucidate the regulatory mechanisms governing CD300a and CD300f.
  • To examine the impact of CD300a and CD300f on the development and progression of diseases.

Main Methods:

  • Literature review focusing on expression, regulation, and function of CD300a and CD300f.
  • Analysis of existing data on leukocyte biology and immune responses.
  • Synthesis of information regarding disease associations.

Main Results:

  • CD300a and CD300f are key regulators of leukocyte activation, proliferation, differentiation, and migration.
  • Their expression and regulation are critical for maintaining immune homeostasis.
  • Dysregulation is implicated in inflammatory and infectious conditions.

Conclusions:

  • CD300a and CD300f are vital inhibitory receptors influencing leukocyte function and immunity.
  • Their regulatory mechanisms and effects on diseases highlight their potential as therapeutic targets.
  • Further research into CD300a and CD300f is warranted for understanding and treating various diseases.