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Related Experiment Videos

Cimetidine does not inhibit plasma cholinesterase activity.

D R Cook1, R L Stiller, S Chakravorti

  • 1Department of Anesthesiology, Children's Hospital of Pittsburgh, Pennsylvania.

Anesthesia and Analgesia
|April 1, 1988
PubMed
Summary

Cimetidine prolongs the effects of succinylcholine, a muscle relaxant. This study found cimetidine does not break down succinylcholine in plasma, suggesting its action occurs elsewhere in the body.

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Area of Science:

  • Pharmacology
  • Anesthesiology
  • Biochemistry

Background:

  • Cimetidine is known to extend the duration of action for succinylcholine.
  • The mechanism behind this interaction remains unclear.
  • Succinylcholine's action is terminated by hydrolysis in plasma.

Purpose of the Study:

  • To investigate the mechanism by which cimetidine increases the duration of action of succinylcholine.
  • To determine if cimetidine inhibits the hydrolysis of succinylcholine by human plasma cholinesterase.

Main Methods:

  • Succinylcholine hydrolysis rate was measured using a modified spectrophotometric assay.
  • Experiments were conducted with varying concentrations of cimetidine (1-50 µg/ml).

Main Results:

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  • Cimetidine did not inhibit the hydrolysis of succinylcholine at concentrations up to 50 µg/ml.
  • The rate of succinylcholine breakdown in human plasma was unaffected by cimetidine.

Conclusions:

  • Cimetidine does not appear to exert its effect on succinylcholine duration by inhibiting plasma cholinesterase.
  • The interaction likely involves a mechanism at the neuromuscular junction rather than plasma hydrolysis.