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Published on: January 26, 2018
Histone crotonylation-centric gene regulation
Kun Li1, Ziqiang Wang2,3
1Department of Nuclear Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China.
Abstract:
Histone crotonylation is a recently described post-translational modification that occurs at multiple identified histone lysine crotonylation sites. An increasing number of studies have demonstrated that histone crotonylation at DNA regulatory elements plays an important role in the activation of gene transcription. However, among others, we have shown that elevated cellular crotonylation levels result in the inhibition of endocytosis-related gene expression and pro-growth gene expression, implicating the complexity of histone crotonylation in gene regulation. Therefore, it is important to understand how histone crotonylation is regulated and how it, in turn, regulates the expression of its target genes. In this review, we summarize the regulatory factors that control histone crotonylation and discuss the role of different histone crotonylation sites in regulating gene expression, while providing novel insights into the central role of histone crotonylation in gene regulation.
Insights
Histone crotonylation, a post-translational modification, regulates gene transcription. This review explores its regulatory factors and diverse roles in gene expression, highlighting its complexity.
Area of Science:
- Biochemistry
- Molecular Biology
- Epigenetics
Background:
- Histone crotonylation is an emerging post-translational modification.
- It is found at multiple histone lysine sites.
- It plays a role in gene transcription regulation.
Purpose of the Study:
- To summarize regulatory factors of histone crotonylation.
- To discuss the role of different histone crotonylation sites in gene expression.
- To provide insights into the complex role of histone crotonylation in gene regulation.
Main Methods:
- Literature review of histone crotonylation.
- Analysis of regulatory factors.
- Discussion of gene expression regulation by histone crotonylation sites.
Main Results:
- Histone crotonylation is involved in both gene activation and inhibition.
- Elevated crotonylation can inhibit endocytosis and pro-growth genes.
- Different crotonylation sites have distinct regulatory roles.
Conclusions:
- Histone crotonylation's role in gene regulation is complex and multifaceted.
- Understanding its regulation is crucial for deciphering its impact on gene expression.
- Further research is needed to fully elucidate the mechanisms of histone crotonylation in gene regulation.
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