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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Related Experiment Video

Updated: Nov 18, 2025

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
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Dysphagia in Older Adults.

Shanojan Thiyagalingam1, Anne E Kulinski2, Bjorg Thorsteinsdottir3

  • 1Division of Geriatric Medicine and Gerontology, Department of Medicine, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, MN.

Mayo Clinic Proceedings
|February 7, 2021
PubMed
Summary

Dysphagia, a geriatric syndrome impacting older adults, can be diagnosed by asking five key questions. Early identification and tailored treatments improve patient outcomes and reduce complications like malnutrition and pneumonia.

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Area of Science:

  • Geriatric Medicine
  • Neurology
  • Gastroenterology

Background:

  • Dysphagia affects 10-33% of older adults, often linked to stroke, Alzheimer's, or Parkinson's disease.
  • Complications include malnutrition, pneumonia, dehydration, increased mortality, and long-term care admission.

Purpose of the Study:

  • To highlight the diagnostic utility of a five-question patient history for identifying dysphagia types.
  • To outline current diagnostic and treatment strategies for oropharyngeal and esophageal dysphagia.

Main Methods:

  • Patient history assessment with five specific questions.
  • Diagnostic imaging: videofluoroscopic swallow study, fiberoptic endoscopic evaluation of swallowing, barium esophagraphy, esophagogastroduodenoscopy (EGD).

Main Results:

  • A five-question history can identify the specific type of dysphagia in approximately 80% of patients.
  • Oropharyngeal dysphagia treatment involves compensatory and rehabilitative interventions.
  • Esophageal dysphagia treatment focuses on managing the underlying cause.

Conclusions:

  • A targeted patient history is crucial for efficient dysphagia diagnosis.
  • Multifaceted treatment approaches are available for different dysphagia types.
  • Further research is needed to optimize the management of this prevalent geriatric syndrome.