Related Experiment Video
Updated: Nov 18, 2025
Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
Published on: November 17, 2018
Impact of antibiotic therapy on the rate of negative test results for chronic endometritis: a prospective randomized
Dongmei Song1, Yanfei He2, Yixuan Wang3
1Department of Hysteroscopic Centre, Fuxing Hospital, the Eighth Clinical Medical College, Capital Medical University, Beijing, People's Republic of China.
Objective:
To compare the rates of negative test results for chronic endometritis (CE) between subjects who did and did not receive antibiotic treatment.
Design:
Prospective, single-blind randomized controlled trial.
Setting:
Tertiary hysteroscopic center in a university teaching hospital.
Patient(S):
A total of 132 women with CE confirmed with immunohistochemical study with CD138 epitope.
Intervention(S):
Women randomized to antibiotic therapy received oral levofloxacin 500 mg and tinidazole 1,000 mg daily for 14 days. Women randomized to the control group did not receive any treatment. A repeated endometrial biopsy was performed 4 to 8 weeks after the initial biopsy to determine whether CE was still present.
Main Outcome Measure(S):
The rate of negative test results for CE (from positive to negative).
Result(S):
The CE rate of negative test results in the treatment group (89.3%) after one course of antibiotic treatment was significantly higher than that in the control group (12.7%). Among subjects who attempted pregnancy, there was no significant difference in ongoing pregnancy rates and miscarriage rates between the treatment arm (43.2%, 5.4%) and the control arm (25.7%, 14.3%). Among subjects randomized, there was also no significant difference in ongoing pregnancy rates and miscarriage rates between the treatment arm (27.1%, 3.4%) and the control arm (16.4%, 9.1%).
Conclusion:
A course of broad-spectrum oral antibiotic therapy for 14 days is effective in the treatment of CE in >89.8% of cases. However, it is not yet clear whether treatment improved pregnancy outcomes.
Clinical Trial Identification Number:
NCT02648698.
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