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Remdesivir for treatment of COVID-19; an updated systematic review and meta-analysis

Afra Rezagholizadeh1, Sajad Khiali1, Parvin Sarbakhsh2

  • 1Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

European Journal of Pharmacology
|February 7, 2021
PubMed

Insights

Remdesivir treatment for COVID-19 significantly improves patient recovery and reduces the need for oxygen support and mechanical ventilation. This antiviral agent also shows a lower risk of serious adverse drug reactions, with a 5-day course appearing as effective as a 10-day course.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Critical Care Medicine

Background:

  • The COVID-19 pandemic presents a global health crisis.
  • Remdesivir is an FDA-approved antiviral for COVID-19 treatment.
  • Evaluating remdesivir's efficacy and safety is crucial.

Purpose of the Study:

  • To systematically review and meta-analyze the efficacy and safety of remdesivir in COVID-19 patients.
  • To assess remdesivir's impact on recovery, oxygen support, and mechanical ventilation.
  • To compare the safety and efficacy of different remdesivir treatment durations.

Main Methods:

  • Systematic literature search across multiple databases (MEDLINE, Scopus, etc.) up to December 2020.
  • Inclusion of five randomized controlled trials (RCTs) and five non-randomized studies of intervention (NRSI).
  • Meta-analysis to pool data on clinical outcomes and adverse drug reactions.

Main Results:

  • Remdesivir significantly improved 28-day recovery rates (RR=1.09).
  • Associated with reduced need for low-flow oxygen (RR=2.88) and mechanical ventilation/ECMO (RR=5.34).
  • Significantly lower risk of serious adverse drug reactions (RR=0.75); 5-day course showed similar benefits with fewer ADRs than 10-day.

Conclusions:

  • Remdesivir demonstrates significant benefits in improving COVID-19 patient outcomes.
  • The 5-day remdesivir regimen may offer comparable efficacy to the 10-day regimen with improved safety.
  • Further well-designed RCTs are warranted for more precise findings.

Keywords:
COVID-19CoronavirusMeta-analysisRemdesivirSARS-CoV-2Systematic review

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