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Related Concept Videos

Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

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Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers,...
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Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

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Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
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Endoscopic Procedures II: Colonoscopy01:25

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The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
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Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

Endoscopic Procedures I: Esophagogastroduodenoscopy

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An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
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Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

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Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

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This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
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Related Experiment Video

Updated: Nov 18, 2025

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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Flexible gastrointestinal endoscope processing challenges, current issues and future perspectives.

N Omidbakhsh1, S Manohar1, R Vu1

  • 1Research & Development Department, Advanced Sterilization Products, Irvine, CA, USA.

The Journal of Hospital Infection
|February 7, 2021
PubMed
Summary
This summary is machine-generated.

Terminal sterilization of flexible gastrointestinal endoscopes is achievable using vaporized hydrogen peroxide. Material compatibility modifications ensure effective sterilization, enhancing patient safety and preventing infections.

Keywords:
DuodenoscopesEndoscope processingHigh-level disinfectionSterility assurance levelSterilizationTerminal sterilizationVaporized hydrogen peroxide sterilizers

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Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
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Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
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Area of Science:

  • Medical device reprocessing
  • Infection control
  • Sterilization technologies

Background:

  • Current flexible gastrointestinal (GI) endoscope processing relies on cleaning and high-level disinfection, often failing to achieve terminal sterilization.
  • Inadequate reprocessing leads to persistent microbial contamination, posing risks of patient infection and fatality.
  • Complex endoscope design, biofilm formation, and limitations of high-level disinfection contribute to processing deficiencies.

Purpose of the Study:

  • To establish the feasibility of terminal sterilization for flexible GI endoscopes.
  • To evaluate vaporized hydrogen peroxide as a sterilization method for endoscopes.

Main Methods:

  • Development of a specific sterilization cycle for vaporized hydrogen peroxide (VHP) systems.
  • Testing VHP sterilization efficacy on colonoscopes and duodenoscopes.
  • Assessment of material compatibility for both standard and modified endoscopes.

Main Results:

  • VHP successfully sterilized flexible GI endoscopes (colonoscopes, duodenoscopes) to a sterility assurance level of 10^-6.
  • No viable microorganisms were recovered from endoscopes artificially contaminated with hard water and serum.
  • Replacing molybdenum disulfide lubricants with graphite-based alternatives improved material compatibility with VHP sterilizers.

Conclusions:

  • Flexible GI endoscopes can be effectively terminally sterilized using VHP technology.
  • Material modifications are crucial for successful VHP sterilization of endoscopes.
  • This approach offers a safer alternative to high-level disinfection, reducing infection risks.