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Low Serum-Free Testosterone Concentration in Chinese Male Patients with Uncomplicated Acute Type B Aortic Dissection
Yu Lun1, Hanbo Liu2, Han Jiang1
1Department of Vascular Surgery, The First Hospital, China Medical University, Shenyang, China.
Insights
Low free testosterone levels are linked to uncomplicated, acute type B aortic dissection in Chinese men. This finding suggests a potential role for androgens in the condition
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Andrology
Background:
- Aortic dissection predominantly affects men, but the role of androgens remains unclear.
- Understanding risk factors for aortic dissection is crucial for early detection and prevention.
Purpose of the Study:
- To investigate androgen levels in Chinese male patients with uncomplicated, acute type B aortic dissection.
- To determine the association between androgen levels and acute type B aortic dissection.
Main Methods:
- A cross-sectional study involving 192 age-matched male patients.
- Comparison between patients with uncomplicated, acute type B aortic dissection and essential hypertension.
- Analysis of demographic and clinical data, including serum testosterone levels.
Main Results:
- Patients with acute type B aortic dissection had significantly lower serum total and free testosterone levels compared to controls.
- Lower free testosterone was independently associated with uncomplicated, acute type B aortic dissection.
- No significant difference in free testosterone was found across different age groups within the dissection cohort.
Conclusions:
- Reduced free testosterone is an independent risk factor for uncomplicated, acute type B aortic dissection in Chinese men with hypertension.
- Further research is warranted to explore the link between androgen deficiency and the earlier onset of aortic dissection in Chinese patients.
Objective:
Although aortic dissection occurs predominantly in men, its association with androgens is unknown. The aim of this study was to evaluate the androgen levels in Chinese male patients with uncomplicated, acute type B aortic dissection.
Study Design:
Cross-sectional study.
Materials And Methods:
A total of 192 age-matched male patients with uncomplicated, acute type B aortic dissection or essential hypertension were recruited between 2016 and 2018. The demographic and clinical data were analyzed.
Results:
Male patients with uncomplicated, acute type B aortic dissection had lower serum total testosterone and free testosterone than male patients with essential hypertension (7.6 ± 3.7 nmol/L vs. 10.9 ± 3.8 nmol/L, P < 0.001; 36.0 ± 19.8 pmol/L vs. 56.4 ± 19.2 pmol/L, P < 0.001). Lower free testosterone level was significantly associated with uncomplicated, acute type B aortic dissection (univariate odds ratio 0.948, P < 0.001; multivariate odds ratio = 0.966, P = 0.002). No statistical difference was observed for free testosterone between younger patient groups (aged < 51 years; aged 51-60 years) and older patient groups (aged 61-70 years; aged >70 years) with uncomplicated, acute type B aortic dissection (33.7 ± 19.8 pmol/L vs. 38.5 ± 19.8 pmol/L, P = 0.239).
Conclusions:
Lower free testosterone was independently associated with uncomplicated, acute type B aortic dissection in the Chinese male population with hypertension. Additional studies are needed to clarify whether earlier onset in Chinese patients with aortic dissection is associated with androgen deficiency.
