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Development of mAb-loaded 3D-printed (FDM) implantable devices based on PLGA.

E Carlier1, S Marquette2, C Peerboom2

  • 1Laboratory of Pharmaceutics and Biopharmaceutics, Université libre de Bruxelles, Faculty of Pharmacy, 1050 Brussels, Belgium.

International Journal of Pharmaceutics
|February 7, 2021
PubMed
Summary

This study demonstrates the feasibility of 3D printing implantable drug delivery systems using fused-deposition modeling (FDM) to load monoclonal antibodies (mAbs). Optimized processes ensure mAb stability, enabling sustained release from 3D-printed devices.

Keywords:
3D printingFused deposition modellingImplantable systemsMonoclonal antibody

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Area of Science:

  • Biomaterials Science
  • Pharmaceutical Technology
  • Drug Delivery Systems

Background:

  • Monoclonal antibodies (mAbs) are crucial therapeutics but face challenges in formulation and delivery.
  • Developing advanced drug delivery systems is essential for controlled and sustained release of biologics like mAbs.
  • Fused-deposition modeling (FDM) offers potential for creating complex, customized implantable devices.

Purpose of the Study:

  • To investigate the feasibility of fabricating mAb-loaded implantable systems using FDM.
  • To optimize stabilization and printing processes for maintaining mAb integrity and function.
  • To evaluate the stability, release profiles, and binding capacity of mAbs in 3D-printed devices.

Main Methods:

  • mAb stabilization using various excipients (trehalose, sucrose, etc.) followed by spray drying.
  • Fabrication of printable filaments via hot melt extrusion (HME) using poly(lactide-co-glycolide) (PLGA) and mAb powder.
  • Optimization of the FDM process to ensure mAb stability during printing.
  • Evaluation of mAb stability (high and low molecular weight species) and binding capacity.

Main Results:

  • Trehalose (TRE) and L-leucine (LEU) were identified as optimal excipients for stabilizing mAbs during HME and FDM.
  • 3D-printed devices exhibited sustained mAb release with a minimal burst effect.
  • The mAb-binding capacity was retained up to 70% after the entire fabrication process.
  • mAb-loaded devices demonstrated good stability and affinity.

Conclusions:

  • Fused-deposition modeling (FDM) is a viable technique for producing complex, implantable mAb-loaded devices.
  • The developed fabrication process ensures mAb stability and preserves therapeutic function.
  • These 3D-printed systems offer promising sustained-release profiles for monoclonal antibody therapy.