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Case report: Isolated muscle neuromyotonia, as presenting feature of Isaacs' syndrome
Volodymyr Samogalskyi1, Yifat Alcalay2, Avi Gadoth3
1Neurology Department, Kaplan Medical Center, Rehovot, Israel.
Abstract:
An autoimmune form of Isaacs' syndrome is commonly associated with VGKC complex antibodies and characterized by continuous muscle activity of extremity muscles. Here, we describe a CASPR2 and LGI1 positive patient with neuromyotonia clinically and electrophysiologically isolated to gastrocnemius muscles only. IVIG course and plasma exchange were ineffective, but symptoms significantly improved after a course of high-dose steroids. This case demonstrates that focal hyperexcitability should raise suspicion for autoimmunity. LGI1 antibody can be positive in patients with only peripheral nerve system involvement and if one treatment fails, other should be tried.
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