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The emerging roles of IDO2 in cancer and its potential as a therapeutic target

Pengcheng Li1, Weiqi Xu1, Furong Liu1

  • 1Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 7, 2021
PubMed

Insights

Tryptophan metabolism, specifically the enzyme Indoleamine 2,3-dioxygenase 2 (IDO2), is increasingly linked to cancer development. This review explores IDO2

Area of Science:

  • Biochemistry
  • Oncology
  • Metabolic pathways

Background:

  • Tryptophan metabolism disorders are implicated in cancer development.
  • Indoleamine 2,3-dioxygenase 2 (IDO2) is a key enzyme in tryptophan catabolism via the kynurenine pathway.
  • IDO2 upregulation in tumors suggests a role in cancer progression.

Purpose of the Study:

  • To review current knowledge on the biological features and regulation of IDO2.
  • To examine the expression and specific roles of IDO2 in various cancers.
  • To discuss the therapeutic potential of targeting IDO2 in cancer treatment.

Main Methods:

  • Literature review of existing research on IDO2 and cancer.
  • Analysis of studies reporting IDO2 expression in tumors.
  • Synthesis of data on IDO2's functional roles in oncogenesis.

Main Results:

  • IDO2 exhibits specific biological characteristics and regulatory mechanisms.
  • IDO2 is expressed in several types of human cancers.
  • IDO2 contributes to cancer development through various mechanisms.

Conclusions:

  • IDO2 plays a significant role in cancer biology.
  • Targeting IDO2 presents a promising therapeutic strategy for cancer treatment.
Keywords:
2,3-dioxygenase 2/IDO2Cancer immunotherapyIndoleamineKynurenine pathwayTherapeutic targetTryptophan metabolism

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