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Related Experiment Video

Updated: Nov 18, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

697

'Methyl palmitate attenuates adjuvant induced arthritis in rats by decrease of CD68 synovial macrophages.

Gehad A Abdel Jaleel1, Samar S Azab2, Wesam M El-Bakly3

  • 1Pharmacology Department, National Research Centre, Giza 12622, Egypt.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|February 7, 2021
PubMed
Summary
This summary is machine-generated.

Methyl palmitate demonstrated significant anti-arthritic effects in a rat model, reducing inflammation and joint swelling. It also inhibited CD68 macrophage expression, suggesting therapeutic potential for rheumatoid arthritis.

Keywords:
Adjuvant induced arthritisCD68Methyl palmitateRats

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Area of Science:

  • Pharmacology
  • Immunology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a chronic inflammatory disease.
  • Adjuvant arthritis in rats shares histopathological similarities with human RA.
  • Investigating novel therapeutic agents for RA is crucial.

Purpose of the Study:

  • To evaluate the anti-arthritic effects of methyl palmitate (MP) in a rat model.
  • To explore the underlying mechanism, including the role of CD68 macrophages.
  • To assess MP's impact on inflammatory markers and immune organ indices.

Main Methods:

  • Adjuvant arthritis was induced in rats using Complete Freund's Adjuvant (CFA).
  • Rats received varying doses of methyl palmitate (75, 150, 300 mg/kg/week) intraperitoneally for 3 weeks.
  • Paw swelling, ankle diameter, spleen and thymus indices, TNF-α, IL-1β, and CD68 expression were measured.

Main Results:

  • Methyl palmitate significantly reduced paw swelling and ankle diameter in a dose-dependent manner.
  • MP treatment decreased spleen and thymus indices, along with serum levels of TNF-α and IL-1β.
  • Expression of CD68 macrophages and synovial inflammatory cellularity were inhibited.

Conclusions:

  • Methyl palmitate exhibits significant anti-inflammatory and anti-arthritic properties in an adjuvant arthritis rat model.
  • MP's inhibition of synovial CD68 macrophages supports its therapeutic potential for inflammatory arthritis.
  • Methyl palmitate warrants further investigation as a potential treatment for rheumatoid arthritis.