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Infant Auditory Processing and Event-related Brain Oscillations
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White matter microstructural differences underlying beta oscillations during speech in adults who stutter.

Fatemeh Mollaei1, Anna Mersov2, Merron Woodbury3

  • 1Department of Speech-Language Pathology, University of Toronto, 500 University Street, Toronto, Ontario M5G 1V7, Canada; Program in Neurosciences and Mental Health, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada.

Brain and Language
|February 7, 2021
PubMed
Summary

Adults who stutter show abnormal brain activity and reduced white matter integrity in the basal ganglia-thalamocortical (BGTC) loop. This study links structural brain deficits to functional speech impairments in developmental stuttering.

Keywords:
Developmental stutteringDiffusion tensor imagingMagnetoencephalographyProbabilistic tractographySpeech productionWhite matter

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Area of Science:

  • Neuroscience
  • Speech and Language Sciences
  • Neuroimaging

Background:

  • Developmental stuttering is associated with speech deficits potentially linked to the basal ganglia-thalamocortical (BGTC) loop.
  • Understanding the interplay between neural oscillations and white matter integrity is crucial for elucidating stuttering mechanisms.

Purpose of the Study:

  • To investigate the relationship between abnormal cortical neural oscillations and structural integrity in the BGTC loop of adults who stutter (AWS).
  • To utilize a novel magnetoencephalography (MEG) guided tractography approach to examine white matter pathways.

Main Methods:

  • Analyzed beta oscillations using sensorimotor speech MEG in 11 AWS and 11 fluent speakers.
  • Examined white matter integrity using tract-based spatial statistics (TBSS) and probabilistic tractography.
  • Applied MEG-guided tractography to assess structural integrity within the BGTC loop.

Main Results:

  • Found overlap between increased beta suppression in the mouth motor area and reduced fractional anisotropy (FA) in AWS.
  • MEG-guided tractography revealed reduced FA within the BGTC loop, specifically from the left putamen to the MEG peak.
  • Identified a network deficit within the BGTC loop, including the left ventral premotor cortex and putamen.

Conclusions:

  • This study provides the first evidence linking structural abnormalities to functional deficits in stuttering.
  • Results suggest a network deficit within the BGTC loop underlies speech impairments in adults who stutter.