MDSCs, ageing and inflammageing
Graham Pawelec1, Emilie Picard2, Valquiria Bueno3
1Department of Immunology, University of Tübingen, Tübingen, Germany; Health Sciences North Research Institute, Sudbury, Ontario, Canada.
Cellular Immunology
|February 7, 2021
Summary
Distinguishing age-related immune changes from pathology is difficult, especially for myeloid-derived suppressor cells (MDSCs). Research in humans must consider both aging and disease contexts for MDSCs.
Area of Science:
- Immunology
- Gerontology
- Cell Biology
Background:
- Distinguishing age-related immune system changes from pathology is challenging.
- Older adults exhibit altered hematopoiesis with a myelopoietic bias.
- "Inflammageing" in older adults, worsened by disease, promotes MDSC induction.
Purpose of the Study:
- To provide an overview of the current literature on myeloid-derived suppressor cells (MDSCs) and aging in humans.
- To highlight the complexities in studying MDSCs in the context of aging and disease.
Main Methods:
- Literature review of studies on MDSCs and aging in humans.
- Analysis of hematopoiesis and inflammageing in older adults.
Main Results:
- Hematopoiesis in older adults shows a bias towards myelopoiesis.
- Inflammageing exacerbates disease and contributes to MDSC induction.
- MDSC investigation in humans is intrinsically linked to aging and disease states.
Conclusions:
- Studying MDSCs in humans requires considering both aging and disease.
- Age-related immune changes and pathology are intertwined, particularly concerning MDSCs.
- Further research is needed to elucidate the specific roles of MDSCs in human aging and disease progression.
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