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Related Experiment Video

Updated: Nov 18, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

MDSCs, ageing and inflammageing.

Graham Pawelec¹, Emilie Picard², Valquiria Bueno³

¹Department of Immunology, University of Tübingen, Tübingen, Germany; Health Sciences North Research Institute, Sudbury, Ontario, Canada.

Cellular Immunology

|February 7, 2021

Summary

This summary is machine-generated.

Distinguishing age-related immune changes from pathology is difficult, especially for myeloid-derived suppressor cells (MDSCs). Research in humans must consider both aging and disease contexts for MDSCs.

Keywords:

Age-associated diseases Healthy ageing Immunosenescence Inflammageing Myeloid-derived suppressor cells

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Last Updated: Nov 18, 2025

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Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

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Published on: February 16, 2017

Area of Science:

Immunology
Gerontology
Cell Biology

Background:

Distinguishing age-related immune system changes from pathology is challenging.
Older adults exhibit altered hematopoiesis with a myelopoietic bias.
"Inflammageing" in older adults, worsened by disease, promotes MDSC induction.

Purpose of the Study:

To provide an overview of the current literature on myeloid-derived suppressor cells (MDSCs) and aging in humans.
To highlight the complexities in studying MDSCs in the context of aging and disease.

Main Methods:

Literature review of studies on MDSCs and aging in humans.
Analysis of hematopoiesis and inflammageing in older adults.

Main Results:

Hematopoiesis in older adults shows a bias towards myelopoiesis.
Inflammageing exacerbates disease and contributes to MDSC induction.
MDSC investigation in humans is intrinsically linked to aging and disease states.

Conclusions:

Studying MDSCs in humans requires considering both aging and disease.
Age-related immune changes and pathology are intertwined, particularly concerning MDSCs.
Further research is needed to elucidate the specific roles of MDSCs in human aging and disease progression.