[Surgical Role for Multiple Primary Lung Cancer]

Area of Science:

• Thoracic Surgery
• Surgical Oncology
• Pulmonary Medicine

Background:

• Secondary primary lung cancer (SPLC) presents unique challenges in management.
• Understanding the outcomes of repeat pulmonary resections is crucial for patient care.
• Evaluating clinicopathological and surgical factors aids in optimizing treatment strategies for SPLC.

Purpose of the Study:

• To investigate the clinicopathological and surgical characteristics of patients undergoing second pulmonary resection for SPLC.
• To determine the prognostic outcomes, including recurrence-free survival (RFS) and overall survival (OS), following repeat lung cancer surgery.

Main Methods:

• Retrospective analysis of 35 patients who underwent second pulmonary resection for non-small cell lung cancer between 2009 and 2016.
• Data collected included patient demographics, tumor characteristics, surgical procedures, and survival outcomes.
• Analysis of synchronous versus metachronous SPLC and their impact on survival.

Main Results:

• The five-year RFS rate was 74.1%, and the five-year OS rate was 85.7%.
• Tumor size of SPLC was significantly smaller than the first primary lung cancer.
• No significant differences in RFS or OS were observed between synchronous and metachronous SPLC groups, nor were surgical procedures or cancer profile associated with survival.

Conclusions:

• Surgical resection for SPLC is a viable and tolerable option, even when lobectomy is required for curative resection.
• Repeat pulmonary resection offers favorable long-term survival for selected patients with SPLC.
• Further research may refine patient selection and surgical approaches for SPLC.