Invasive and Non-invasive Neurostimulation for OCD
Isidoor O Bergfeld1,2, Eva Dijkstra1, Ilse Graat1
1Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Current Topics in Behavioral Neurosciences
|February 7, 2021
Summary
Neurostimulation, including deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS), offers effective treatment for obsessive-compulsive disorder (OCD). Targeting specific brain circuits shows significant patient response rates, improving lives.
Area of Science:
- Neuroscience
- Psychiatry
- Neuromodulation
Background:
- Obsessive-compulsive disorder (OCD) is a debilitating condition.
- Treatment-refractory OCD poses significant challenges for patient management.
- Neurostimulation techniques are emerging as promising therapeutic options.
Purpose of the Study:
- To review evidence on neurostimulation techniques for OCD.
- To analyze clinical results, mechanisms, and animal research.
- To explore optimization strategies for neurostimulation treatments.
Main Methods:
- Focus on deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS).
- Review of clinical studies, including a meta-analysis.
- Inclusion of neuroimaging and animal research for mechanistic insights.
Main Results:
- Deep brain stimulation (DBS) targeting the ventral capsule/ventral striatum (VC/VS) shows a 76% response rate in treatment-refractory OCD.
- Non-invasive transcranial magnetic stimulation (TMS) also demonstrates clinical promise.
- Neuroimaging and animal studies elucidate normalizing effects on cortico-striatal-thalamic-cortical (CSTC) loops.
Conclusions:
- Neurostimulation is an effective treatment for obsessive-compulsive disorder (OCD).
- Understanding effects on CSTC loops offers avenues for treatment optimization.
- Advancing clinical implementation is crucial for improving patient outcomes.
Keywords:
Deep brain stimulationNeuromodulationTranscranial magnetic stimulationTreatment outcomeWorking mechanismsMore Related Videos
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