[Stress response induced by burn injury and its regulation strategy]

Severe burns trigger the stress response, cause different degrees of damage to the body, and participate in the occurrence and development of immune dysfunction and hypermetabolism after burn. Rational application of analgesic and sedative drugs is the major method of inhibiting the severe burn-induced stress response, which can alleviate the organ damages and reduce the incidence of burn sepsis. Furthermore, integrated approaches including wound management, infection control, nutritional support, and gastrointestinal tract protection, as well as sleep management, etc., collectively contribute to the alleviation of stress response after burn injury. To further improve the success rate of severe burn treatment, it is essential to study the changes of various stresses, endocrine hormones and immune patterns in patients with severe burn, to explore the mechanism and regulation of burn-induced hypermetabolism, and to reach a consensus on sedation and analgesia strategy, the management of stress response and hypermetabolism after severe burns.