COVID-19 Convalescent Plasma: from donation to treatment - A Systematic Review & Single Center Experience

Area of Science:

• Immunology
• Infectious Diseases
• Hematology

Background:

• The coronavirus disease 2019 (COVID-19) pandemic necessitated exploring novel and repurposed therapeutic strategies.
• Convalescent plasma, derived from recovered patients, has a history of use in treating viral infections.
• The efficacy and implementation of convalescent plasma for COVID-19 required thorough investigation.

Purpose of the Study:

• To systematically review current research on convalescent plasma as a treatment for COVID-19.
• To describe the practical experience of creating and managing a single-center convalescent plasma donation program.

Main Methods:

• A systematic literature review was conducted to synthesize existing studies on convalescent plasma for COVID-19.
• The establishment of a convalescent plasma donation program was detailed, outlining operational aspects.

Main Results:

• The systematic review summarized the available evidence regarding convalescent plasma therapy in COVID-19 patients.
• The description of the donation program provided insights into logistical and operational considerations.

Conclusions:

• Convalescent plasma emerged as a potential therapeutic option during the COVID-19 pandemic.
• The establishment of donation programs is crucial for facilitating the use of convalescent plasma in clinical settings.