Related Experiment Video
Updated: Nov 18, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Evaluation of the correlation between dental caries and periodontitis - A clinico- immunological analysis
Janani Balachandran1, N Gurucharan1
1Department of Conservative Dentistry and Endodontics, Rajah Muthiah Dental College and Hospital, Annamalai University, Chidambaram, Tamil Nadu, India.
Background:
To study the correlation between dental caries and periodontitis.
Aim:
The aim of the study was to evaluate the correlation between dental caries and periodontitis based on the clinical and immunological analysis. The null hypothesis was that there is no clinical and immunological correlation between dental caries and periodontitis.
Settings And Design:
Fifty systemically healthy adults (mean age of 35 years) with decayed, missing, and filled teeth scores of more than 6 were assessed for periodontal health by recording their probing depth (PD) and bleeding on probing (BOP) values. Unstimulated whole saliva was collected, and enzyme-linked immunosorbent assay (ELISA) analysis was conducted for determining the immunoglobulin A (IgA) and immunoglobulin G (IgG) levels. The obtained clinical and immunological values were statistically analyzed.
Results:
The results of the clinical examination revealed low PD and BOP scores, whereas the ELISA analysis showed significantly higher salivary IgA levels as compared to salivary IgG.
Conclusions:
Based on the observations of this clinicoimmunological study, it was concluded that no correlation existed between dental caries and periodontal disease.
Related Concept Videos
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
Assessment of the Mouth
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.

