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Age-Related Pathways in Cardiac Regeneration: A Role for lncRNAs?

Francisco Santos1, Magda Correia1, Sandrina Nóbrega-Pereira1,2

  • 1Department of Medical Sciences and Institute of Biomedicine - iBiMED, University of Aveiro, Aveiro, Portugal.

Frontiers in Physiology
|February 8, 2021
PubMed

Insights

Aging impairs heart regeneration by altering cardiac structure and function, increasing heart failure risk. Long non-coding RNAs (lncRNAs) show promise as therapeutic targets for cardiac repair in aging hearts.

Area of Science:

  • Cardiovascular Biology
  • Aging Research
  • Molecular Medicine

Background:

  • Aging significantly alters cardiac structure and function, elevating heart failure risk.
  • Age-related molecular pathways increase susceptibility to cardiac disease.
  • Limited understanding of molecular mechanisms in cardiac aging and repair.

Purpose of the Study:

  • To summarize molecular and physiological changes during cardiac aging.
  • To highlight the potential of long non-coding RNAs (lncRNAs) in cardiac regeneration.

Main Methods:

  • Review of existing literature on cardiac aging.
  • Analysis of molecular and physiological alterations.
  • Focus on the role of lncRNAs in cardiac repair.

Main Results:

  • Aging causes significant cardiac structural and functional changes.
  • Multiple pathways contribute to age-related cardiac decline.
  • lncRNAs emerge as critical players in cardiac aging and repair.

Conclusions:

  • Understanding cardiac aging is crucial for developing regenerative strategies.
  • lncRNAs represent promising targets for enhancing cardiac repair in aging individuals.

Keywords:
heartlncRNAsregenerationreprogrammingtransdifferentiation

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