Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ciliary abnormalities in respiratory disease.

R M Buchdahl1, J Reiser, D Ingram

  • 1Paediatric Respiratory Department, Brompton Hospital, London.

Archives of Disease in Childhood
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COVID-19: Extensive epithelial damage and ciliary dyskinesia in hospitalised patients.

Rhinology·2022
Same author

Effect of nocturnal Temperature-controlled Laminar Airflow on the reduction of severe exacerbations in patients with severe allergic asthma: a meta-analysis.

European clinical respiratory journal·2021
Same author

Time to onset of improvements in Quality of Life from Temperature-controlled Laminar Airflow (TLA) in severe allergic asthma.

Respiratory medicine·2019
Same author

Validation of the Children's Sleep Habits Questionnaire in a sample of Greek children with allergic rhinitis.

Allergologia et immunopathologia·2018
Same author

A brief psychological intervention for mothers of children with food allergy can change risk perception and reduce anxiety: Outcomes of a randomized controlled trial.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017
Same author

A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies.

Molecular psychiatry·2017
Same journal

Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study.

Archives of disease in childhood·2026
Same journal

Artificial intelligence for child health: current capabilities and the next frontier.

Archives of disease in childhood·2026
Same journal

Troubled origins and lasting impact of the first insulin injection.

Archives of disease in childhood·2026
Same journal

Paediatric readiness assessment tools in emergency care: a scoping review.

Archives of disease in childhood·2026
Same journal

Building a paediatric workforce to deliver the NHS prevention agenda: time for paediatric public health medicine?

Archives of disease in childhood·2026
Same journal

Impact of antenatal biological response modifying drugs on infant infection risk and vaccination rates: a national cohort study.

Archives of disease in childhood·2026
See all related articles

Children with chronic respiratory issues may have ciliary dyskinesia, a condition affecting cilia function. Early investigation is recommended, especially for those with symptoms from birth.

Area of Science:

  • Pediatric Pulmonology
  • Cell Biology
  • Genetics

Background:

  • Chronic respiratory diseases in children present a significant clinical challenge.
  • Ciliary dyskinesia (CD) is a rare genetic disorder affecting mucociliary clearance.
  • Accurate diagnosis of CD is crucial for appropriate management and genetic counseling.

Observation:

  • 167 children with chronic respiratory problems were evaluated for ciliary function.
  • Abnormal ciliary function was identified in 18 children (10.8%), all with chronic lower respiratory disease.
  • Perinatal respiratory symptoms were more prevalent in children with diagnosed ciliary dyskinesia.

Findings:

  • Reduced ciliary beat frequency (<10 Hz) was observed in 15 out of 18 CD cases.
  • Three cases exhibited an apparent absence of ciliated cells.

Related Experiment Videos

  • Ultrastructural analysis revealed normal cilia in 7 CD cases and abnormalities (missing dynein arms, microtubular defects) in 8 cases.

    • Implications:

    • Suggests ciliary dyskinesia should be investigated in children with unexplained chronic respiratory disease.
    • Highlights the importance of considering CD in cases with a history of perinatal respiratory symptoms.
    • Emphasizes the need for further research into the genetic and clinical spectrum of pediatric ciliary dyskinesia.