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Updated: Nov 18, 2025

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Published on: May 12, 2011
Trans-synaptic degeneration of the optic radiation from optic nerve atrophy
Shingo Kihira1, Anthony C Arnold2, Puneet S Pawha1
1Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abstract:
Fourty-seven-year-old woman with 5-year history of progressive decreased left eye vision. Optical coherence tomography showed optic nerve atrophy (left > right) and brain MRI revealed T2 hyperintense signal along the course of left optic radiations. We present a case of a trans-synaptic degeneration of the optic radiation in a patient with confirmed optic atrophy. Trans-synaptic degeneration of the optic radiation without associated infarct or inflammatory disease has not been reported before in patients with optic atrophy.
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