Related Experiment Video
Updated: Nov 18, 2025

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
Osteomyelitis and pyomyositis due to Staphylococcus aureus in an osteomalacic adult with multiple fractures
Masumi Ogawa1, Takatoshi Kitazawa2, Yusuke Yoshino2
1Department of Internal Medicine, Self-defense Forces Central Hospital, Tokyo, Japan.
Abstract:
Multifocal osteomyelitis and pyomyositis usually arise from hematogenous dissemination, especially in patients with immunodeficiency, trauma, or injection drug abuse. We report the case of a 75-year-old man with multifocal pyomyositis and osteomyelitis, which were due to Staphylococcus aureus and were presumably related to multiple fractures. The patient had no risk factors for these hematogenous infections. He was treated with antibiotic therapy for about 80 days and drainage of the abscesses. Regarding the cause of his multipe fractures, he was found to have hypophosphatemia and eventually diagnosed as osteomalacia. To our best knowledge, this case was the first report on multifocal osteomyelitis and pyomyositis around the fracture sites in an osteomalacic adult. Osteomalacia should be considered as one of the differential diagnoses when osteoarticular infection with multifocal fractures is detected.
Insights
This case study highlights multifocal osteomyelitis and pyomyositis in an adult with osteomalacia and fractures. It suggests osteomalacia as a potential factor in such complex bone infections.
Area of Science:
- Infectious Diseases
- Orthopedics
- Endocrinology
Background:
- Multifocal osteomyelitis and pyomyositis typically result from hematogenous spread, often seen in immunocompromised individuals, trauma patients, or injection drug users.
- This case presents a unique scenario in a 75-year-old man with multifocal osteomyelitis and pyomyositis caused by Staphylococcus aureus, linked to multiple fractures without typical risk factors for hematogenous infection.
More Related Videos
04:37Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
18:40Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice
Published on: October 16, 2014
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Acute Pyelonephritis II: Diagnostic Studies and Management
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
What is the Skeletal System?
Osteoclasts in Bone Remodeling
Acute Pyelonephritis I: Introduction