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Growth Patterns of Thai Children with Down Syndrome from Birth to 5 Years

Naiyana Boontan1, Kitiwan Rojnueangnit1

  • 1Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.

Journal of Pediatric Genetics
|February 8, 2021
PubMed

Insights

This study developed growth charts for Thai children with Down syndrome (DS), revealing they are shorter and lighter than peers globally. Individualized DS growth charts are crucial for accurate monitoring.

Area of Science:

  • Pediatrics
  • Genetics
  • Growth and Development

Background:

  • Specific growth charts for children with Down syndrome (DS) are essential for accurate health monitoring.
  • Thailand currently lacks established growth patterns for pediatric populations with DS.
  • Existing international DS growth charts may not accurately reflect the Thai population.

Purpose of the Study:

  • To develop novel, sex-specific growth patterns for Thai children diagnosed with Down syndrome (DS).
  • To provide clinicians with improved tools for assessing and monitoring growth in Thai children with DS.
  • To establish a baseline for future research on growth in this specific demographic.

Main Methods:

  • Retrospective analysis of 1,681 length/height and weight measurements from 80 children with DS.
  • Data collected from patients receiving care at Thammasat University Hospital between 2014 and 2018.
  • Generation of sex-specific growth patterns, including the 5th, 50th, and 95th percentiles.

Main Results:

  • Thai children with Down syndrome (DS) exhibited lower weight and height compared to general Thai children.
  • Growth patterns indicated that Thai children with DS were shorter and lighter than children with DS in other countries.
  • Significant differences highlight the need for population-specific growth references.

Conclusions:

  • Thailand requires unique Down syndrome (DS) growth charts tailored to its population.
  • Developing country-specific DS growth charts is vital for precise clinical assessment and management.
  • These findings underscore the importance of localized pediatric growth data.

Keywords:
Down syndromeThaichildrengrowth pattern

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