Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Overview of Cell-Matrix Interactions

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nuclear Speckles Regulate Splicing During Muscle Stem Cell Activation and Aging.

bioRxiv : the preprint server for biology·2026

Same author

A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy.

Developmental cell·2026

Same author

Matrix composition modulates cancer cell phenotypes and secretions in a blood-brain barrier organ-on-a-chip model: Comparison of collagen and hyaluronic acid.

Biomaterials·2026

Same author

Longitudinal Single-Cell RNA-seq Profiling of Lung Cell Phenotypes, Signaling, and Cross-talk During Fibrosis Resolution.

bioRxiv : the preprint server for biology·2026

Same author

Functional landscape of non-canonical open reading frames in coordinating cell fate.

Molecular cell·2026

Same author

NCCN Guidelines® Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate, Version 2.2026.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

Same journal

Correction to "Nanoparticles (NPs)-Meditated LncRNA AFAP1-AS1 Silencing to Block Wnt/β-Catenin Signaling Pathway for Synergistic Reversal of Radioresistance and Effective Cancer Radiotherapy".

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Femtosecond-Laser Nanocavitation Regenerates SERS-Active Plasmonic Nanogaps for Longitudinal Molecular Sensing at Biointerfaces.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Correction to "Bioinspired Polyacrylic Acid-Based Dressing: Wet Adhesive, Self-Healing, and Multi-Biofunctional Coacervate Hydrogel Accelerates Wound Healing".

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Non-Line-of-Sight Passive Ammonia Sensor Loaded With MXene/In<sub>2</sub>O<sub>3</sub> Composites for Agricultural Products Quality Deterioration Detection.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Cerium Nanoparticle-Mediated Inhibition of the NSUN2/m<sup>5</sup>C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same journal

Biomimetic Nanoplatform for Dual Target Nano-Metabolic Therapy in Diabetes-Associated Biofilm Infections.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 18, 2025

Silicon Microchips for Manipulating Cell-cell Interaction

Silicon Microchips for Manipulating Cell-cell Interaction

Published on: August 30, 2007

Engineered Tools to Study Intercellular Communication.

Benjamin A Yang¹, Trisha M Westerhof^1,2, Kaitlyn Sabin¹

¹Department of Biomedical Engineering and Biointerfaces Institute 2800 Plymouth Road, North Campus Research Complex Ann Arbor MI A10-183 USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|February 8, 2021

Summary

This summary is machine-generated.

Understanding how cells communicate is key to health and disease. New microengineering and genomics tools help scientists study these complex cell networks to develop better treatments.

Keywords:

biomedical devices cell–cell communication high‐throughput sequencing intercellular communication

More Related Videos

Single-cell Microinjection for Cell Communication Analysis

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling

Published on: January 28, 2021

Related Experiment Videos

Last Updated: Nov 18, 2025

Silicon Microchips for Manipulating Cell-cell Interaction

Silicon Microchips for Manipulating Cell-cell Interaction

Published on: August 30, 2007

Single-cell Microinjection for Cell Communication Analysis

Single-cell Microinjection for Cell Communication Analysis

Published on: February 26, 2017

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling

Silicon Nanowires and Optical Stimulation for Investigations of Intra- and Intercellular Electrical Coupling

Published on: January 28, 2021

Area of Science:

Cellular biology
Systems biology
Bioengineering

Background:

Multicellular organisms depend on intercellular communication for coordinated function and tissue homeostasis.
Understanding cell signaling networks is crucial for disease prevention, aging research, and therapeutic development.
Studying complex in vivo cell networks requires methods that reduce scale and resolve molecular heterogeneity.

Purpose of the Study:

To review how microengineering and high-throughput genomics advance the study of intercellular communication.
To highlight techniques for analyzing collective cell behavior and tissue functions.
To bridge the gap between engineered systems and genomic data for mechanistic insights.

Main Methods:

Microengineering approaches for spatiotemporal control of cellular interactions.
High-throughput genomics for analyzing molecular heterogeneity.
Integration of engineered systems with sequencing techniques.
Review of current literature on advanced cellular communication analysis.

Main Results:

Recent advances enable high-throughput, mechanistic studies of intercellular communication.
Microengineering provides precise control over cellular environments and interactions.
Genomics offers deep insights into cell states and functions within networks.
These integrated approaches allow for a more comprehensive understanding of collective cell behavior.

Conclusions:

Engineered systems combined with advanced sequencing are powerful tools for studying intercellular communication.
These technologies facilitate the mechanistic understanding of cell-cell interactions and tissue homeostasis.
This approach holds significant promise for future research in disease and aging.