Functional Constipation and the Gut Microbiome in Children: Preclinical and Clinical Evidence

Area of Science:

• Pediatric Gastroenterology
• Microbiome Research
• Child Health

Background:

• Functional constipation is a prevalent childhood condition impacting quality of life and healthcare costs.
• Symptoms include infrequent bowel movements and hard stools, causing distress for children and families.
• A significant percentage of children experience persistent constipation into adulthood, indicating unmet treatment needs.

Purpose of the Study:

• To review preclinical and clinical evidence on the gut microbiome's role in pediatric functional constipation.
• To explore potential mechanisms linking gut microbiota to constipation pathophysiology in children.

Main Methods:

• Literature review of preclinical studies.
• Analysis of clinical research investigating the gut microbiome in pediatric functional constipation.

Main Results:

• The gut microbiome is increasingly recognized as a potential factor in functional constipation.
• Evidence suggests specific microbial compositions or functions may contribute to symptom development.
• Further research is needed to fully elucidate these complex interactions.

Conclusions:

• The gut microbiome represents a promising area for understanding and potentially treating pediatric functional constipation.
• Targeting the gut microbiota could offer novel therapeutic strategies for refractory cases.
• This review highlights the importance of considering the microbiome in pediatric constipation management.