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Complement, a Therapeutic Target in Diabetic Kidney Disease.
Kelly Budge1, Sergio Dellepiane1, Samuel Mon-Wei Yu1
1Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Frontiers in Medicine
|February 8, 2021
Summary
Current diabetic kidney disease treatments are limited. Targeting the complement system, a part of immunity, shows promise for halting DKD progression by reducing inflammation.
Area of Science:
- Immunology
- Nephrology
- Pharmacology
Background:
- Diabetic kidney disease (DKD) treatments are insufficient despite advances in understanding its pathology.
- The complement system, crucial for immunity, can cause disease when overactivated, leading to inflammation.
- Evidence indicates complement system activation plays a role in DKD pathogenesis.
Purpose of the Study:
- To review diabetic kidney disease (DKD) and the complement system's role in kidney diseases.
- To explore the potential of complement inhibition as a novel therapeutic strategy for DKD.
- To discuss the benefits of targeting complement pathways in DKD patients.
Main Methods:
- Literature review of DKD pathophysiology.
- Analysis of the complement system's involvement in diabetic and non-diabetic kidney conditions.
- Evaluation of complement inhibition strategies based on existing drug data and clinical outcomes in other kidney diseases.
Main Results:
- Dysregulated complement activation is implicated in DKD.
- Complement inhibition has proven effective in other kidney diseases.
- Targeting the complement system offers a potential new therapeutic avenue for DKD.
Conclusions:
- Complement inhibition represents a promising therapeutic approach for diabetic kidney disease.
- Further research into complement targeting therapies could significantly benefit DKD patients.
- Modulating the complement system may halt or slow the progression of DKD.
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