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Inflammatory Cytokines in Diabetic Kidney Disease: Pathophysiologic and Therapeutic Implications

Javier Donate-Correa1,2, Carla M Ferri1,3, Fátima Sánchez-Quintana1,3

  • 1Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.

Frontiers in Medicine
|February 8, 2021
PubMed

Insights

Diabetic kidney disease (DKD) involves inflammation. Understanding these inflammatory pathways is key to developing new treatments for this diabetes complication.

Area of Science:

  • Nephrology
  • Immunology
  • Endocrinology

Background:

  • Diabetic kidney disease (DKD) is a major cause of end-stage renal disease and cardiovascular complications in diabetes mellitus.
  • Current DKD management focuses on controlling hyperglycemia and hypertension.
  • Inflammation is increasingly recognized as a central pathogenic process in DKD, though its precise mechanisms are not fully understood.

Purpose of the Study:

  • To review the inflammation-related pathogenic mechanisms underlying DKD.
  • To explore the therapeutic potential of novel anti-inflammatory strategies for DKD.

Main Methods:

  • Literature review of studies on DKD pathogenesis and inflammation.
  • Analysis of current and emerging anti-inflammatory therapeutic approaches.

Main Results:

  • Inflammation plays a critical role in the development and progression of DKD.
  • Specific inflammatory pathways contribute to kidney damage in diabetic patients.
  • Emerging anti-inflammatory therapies show promise for DKD treatment.

Conclusions:

  • Targeting inflammation represents a promising therapeutic avenue for managing DKD.
  • Further research into DKD inflammatory mechanisms is crucial for clinical advancement.
  • Anti-inflammatory strategies could offer new hope for patients with diabetic kidney disease.

Keywords:
DPP-4iGLP-1RASGLT2idiabetic kidney diseaseinflammationinflammatory cytokinespentoxifylline

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