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Related Concept Videos

Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

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Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
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ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias01:25

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Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
257
Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

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Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

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Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
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Updated: Nov 18, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Cancer Radiation Therapy May Be Associated With Atrial Fibrillation.

Nachiket Apte1, Parinita Dherange1, Usman Mustafa1

  • 1Department of Medicine and Center of Excellence for Cardiovascular Diseases & Sciences, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, United States.

Frontiers in Cardiovascular Medicine
|February 8, 2021
PubMed
Summary
This summary is machine-generated.

Cancer patients have a higher prevalence of atrial fibrillation (AF). Radiation therapy, used to treat cancer, was identified as an independent risk factor for developing AF.

Keywords:
atrial fibrillationcancerchemotherapyhematological malignanciesradiation therapysolid malignancy

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Area of Science:

  • Cardiology
  • Oncology
  • Medical Research

Background:

  • The relationship between atrial fibrillation (AF) and cancer, including specific cancer types, remains unclear.
  • Existing data on the association between AF and various cancer therapies are conflicting.

Purpose of the Study:

  • To investigate the association between atrial fibrillation (AF) and different cancer subtypes.
  • To examine the link between AF and various cancer treatment modalities.

Main Methods:

  • Analysis of 14,600 patients (aged 18-89) from January 2011 to February 2016 at Feist Weiller Cancer Center.
  • Systematic review of electronic health records for demographics, comorbidities (ICD-9/ICD-10 codes), and AF diagnosis (ECG/history).
  • Assessment of AF prevalence and risk stratified by cancer diagnosis, cancer type, and cancer therapy.

Main Results:

  • Cancer patients exhibited a higher AF prevalence (4.3%) compared to non-cancer patients (3.1%), but malignancy was not an independent risk factor after covariate adjustment.
  • No significant independent association was found between AF and specific tumor types (solid vs. hematological malignancies).
  • AF prevalence was significantly higher in patients receiving radiation therapy (5.1%) or combined chemotherapy and radiation (6.9%) versus no therapy (3.6%). Radiation therapy emerged as an independent risk factor for AF.

Conclusions:

  • Radiation therapy for cancer is an independent risk factor for developing atrial fibrillation (AF).
  • The observed association between cancer and AF may be partly explained by the impact of radiation therapy.