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Circulating immune parameters-based nomogram for predicting malignancy in laryngeal neoplasm.

Min Chen1, Yi Fang1, Yue Yang1

  • 1Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai 200031, China.

World Journal of Clinical Cases
|February 8, 2021
PubMed
Summary
This summary is machine-generated.

This study developed a new nomogram to predict laryngeal cancer malignancy using clinical factors and immune cell data. The tool shows good accuracy for preoperative diagnosis in patients with laryngeal neoplasm.

Keywords:
Circulating immune cellLaryngeal malignant lesionLaryngeal neoplasmLaryngeal premalignant lesionMalignancy predictionNomogram

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Area of Science:

  • Oncology
  • Immunology
  • Medical Diagnostics

Background:

  • Accurate prediction of malignancy is crucial for managing laryngeal neoplasms.
  • Distinguishing between benign, premalignant, and malignant laryngeal lesions preoperatively is challenging.

Purpose of the Study:

  • To assess circulating immune cell populations in patients with laryngeal neoplasm.
  • To develop and validate a nomogram for predicting malignancy in laryngeal neoplasm.

Main Methods:

  • A cohort of 156 patients with laryngeal lesions was analyzed using blood routine tests and flow cytometry.
  • A predictive nomogram was constructed using clinical factors and immune cell parameters.
  • The nomogram was validated in an independent cohort of 55 patients.

Main Results:

  • Significant differences in immune parameters were observed between benign and premalignant lesions.
  • The nomogram, incorporating age, gender, smoking history, and immune cell proportions (monocytes, CD8+ T cells, CD4+ T cells, B cells, CD4/CD8 ratio), demonstrated strong predictive ability (C-index 0.844 primary, 0.804 validation).
  • The nomogram showed good discrimination and calibration, proving clinically useful.

Conclusions:

  • A novel nomogram integrating clinical and immune markers effectively predicts laryngeal malignancy.
  • This tool facilitates preoperative individualized risk assessment for patients with laryngeal neoplasm.
  • The findings support the use of circulating immune profiles in cancer diagnostics.