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Related Experiment Video

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Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
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Chemoradiation induced multiple sclerosis-like demyelination.

Alexandra Borges1,2, Daniela Garcez3, Cátia Pedro4

  • 1Radiology Department, Instituto Português de Oncologia Francisco Gentil, Centro de Lisboa, Rua Prof. Lima Basto, 1099-023 Lisbon, Portugal.

Eneurologicalsci
|February 8, 2021
PubMed
Summary
This summary is machine-generated.

A young man developed multiple sclerosis-like lesions after chemoradiation for a suprasellar germinoma. These lesions, showing intrathecal IgG synthesis, spontaneously resolved, suggesting a delayed demyelination secondary to treatment.

Area of Science:

  • Neuro-oncology
  • Neurology
  • Radiotherapy

Background:

  • Suprasellar germinomas are rare tumors, typically treated with chemoradiation.
Keywords:
Chemorradiation-induced demyelinationChemorradiation-induced neurotoxicityMRIMultiple sclerosis-like demyelinationNeuro-oncology

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  • Chemoradiation can have long-term side effects, including neurological complications.
  • Demyelinating lesions mimicking multiple sclerosis (MS) are a rare potential complication.