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Age-related differences in computed tomographic scan measurements.

J L Stafford1, M S Albert, M A Naeser

  • 1Department of Psychiatry, University of Rochester, NY Medical School.

Archives of Neurology
|April 1, 1988
PubMed
Summary
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Brain imaging reveals significant changes in fluid volume and density with aging. These computed tomography (CT) findings correlate with cognitive function in healthy older men.

Area of Science:

  • Neuroimaging
  • Gerontology
  • Cognitive Neuroscience

Background:

  • Aging is associated with structural brain changes.
  • Understanding age-related brain alterations is crucial for cognitive health.
  • Computed tomography (CT) offers a method to assess brain structure.

Purpose of the Study:

  • To investigate the relationship between age and brain structural measures using CT.
  • To explore the correlation between CT-derived brain metrics and neuropsychological test performance.
  • To identify age-related changes in brain fluid volume and tissue density.

Main Methods:

  • Seventy-nine healthy men aged 31-87 years underwent CT scans.
  • CT slices (midventricular, high ventricular, supraventricular) were analyzed for fluid volume and mean CT density.

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  • Neuropsychological tests were administered to assess cognitive function.
  • Discriminant functions were derived from both CT and neuropsychological data.

    • Main Results:

    • Fluid volume at ventricular levels increased significantly after age 60.
    • Fluid volume above ventricles showed a slight increase in the 50s, then plateaued.
    • Whole slice mean CT density decreased linearly with age.
    • CT-derived discriminant functions correlated significantly with neuropsychological discriminant functions.

    Conclusions:

    • Age-related increases in ventricular fluid volume and decreases in brain tissue density are evident.
    • These structural brain changes are associated with cognitive performance in aging men.
    • Findings highlight the utility of CT in assessing age-related brain changes and their cognitive correlates.