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Multiple myeloma involving the iris.

E P Shakin1, J J Augsburger, R C Eagle

  • 1Oncology Service, Wills Eye Hospital, Philadelphia, PA 19107.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|April 1, 1988
PubMed
Summary
This summary is machine-generated.

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Neoplastic plasma cells can invade the eye, a rare complication of plasma cell dyscrasias. This case highlights iris infiltration mimicking uveitis in a multiple myeloma patient, confirmed by cytology.

Area of Science:

  • Ophthalmology
  • Hematology
  • Oncology

Background:

  • Plasma cell dyscrasias, such as multiple myeloma, are systemic disorders characterized by the proliferation of abnormal plasma cells.
  • Ophthalmic involvement in plasma cell dyscrasias is uncommon, with intraocular invasion being particularly rare.

Observation:

  • A 67-year-old male patient with a known history of multiple myeloma presented with symptoms suggestive of ocular inflammation.
  • The patient exhibited an iris infiltration that clinically mimicked nongranulomatous uveitis, a common inflammatory eye condition.

Findings:

  • Anterior chamber paracentesis was performed to obtain a sample of the intraocular infiltrate.
  • Cytologic examination of the aspirate definitively revealed the presence of neoplastic plasma cells as the cause of the iris infiltration.

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Implications:

  • This case underscores the importance of considering plasma cell dyscrasias in the differential diagnosis of atypical uveitis presentations.
  • Early recognition and diagnosis of intraocular involvement are crucial for appropriate management and potentially preventing further vision loss in patients with multiple myeloma.