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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Cleavage and Blastulation01:33

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After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
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Human Blastocyst Biopsy and Vitrification
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Adding a low-quality blastocyst to a high-quality blastocyst for a double embryo transfer does not decrease pregnancy

Efstathios Theodorou1, Benjamin P Jones2,3, Suzanne Cawood1

  • 1The Centre for Reproductive & Genetic Health (CRGH), London, UK.

Acta Obstetricia Et Gynecologica Scandinavica
|February 8, 2021
PubMed
Summary
This summary is machine-generated.

Transferring a single high-quality blastocyst is recommended when only one is available, as adding a low-quality embryo slightly increases live birth rates but significantly raises the twin rate. Even with multiple high-quality embryos, single transfers offer good success without high twin risks.

Keywords:
blastocystembryo qualityembryo transferin vitro fertilizationlive birth rate

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • In Vitro Fertilization

Background:

  • The impact of transferring a low-quality embryo alongside a high-quality one in assisted reproductive technology (ART) is not fully understood.
  • Some research suggests this combination may reduce live birth rates compared to transferring a single high-quality embryo.

Purpose of the Study:

  • To investigate how the quality of a second blastocyst affects ART outcomes.
  • To control for the number of available high-quality blastocysts (HQB) in the analysis.

Main Methods:

  • A historical cohort study involving 2346 fresh blastocyst transfers.
  • Comparison of outcomes including pregnancy, miscarriage, live birth, and multiple gestation rates.
  • Analysis of single high-quality blastocyst transfers (SET-H), double transfers of two high-quality blastocysts (DET-HH), and transfers of one high-quality and one low-quality blastocyst (DET-HL).

Main Results:

  • When one HQB was available, DET-HL increased live birth rate (LBR) but significantly raised the multiple gestation rate compared to SET-H.
  • When two HQBs were available, DET-HH showed higher LBR and lower miscarriage rates but a very high twin rate compared to SET-H.
  • Single embryo transfers (SET) with available high-quality blastocysts for freezing demonstrated improved LBR compared to SET without surplus high-quality blastocysts.

Conclusions:

  • When one HQB is available, single embryo transfer (SET) is recommended to avoid a significant increase in twin rates.
  • With two or more HQBs, SET-H provides good success rates without the high twin rate associated with double transfers (DET-HH).
  • Double transfers of two low-quality blastocysts (DET-LL) increased LBR compared to SET-L but also increased the risk of multiple gestation.