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Related Experiment Videos

Running-induced changes in lung function are not altered by acute moderate hypoxia.

D S Miles1, R S Schaefer

  • 1Department of Physiology and Biophysics, School of Medicine, College of Science and Mathematics, Wright State University, Dayton, Ohio 45401-0927.

Aviation, Space, and Environmental Medicine
|March 1, 1988
PubMed
Summary

Running in simulated high altitude (normobaric hypoxia) caused similar lung volume changes as normal conditions, primarily due to expiratory limitation, not interstitial edema.

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Area of Science:

  • Exercise Physiology
  • Pulmonary Function Testing
  • Altitude Simulation

Background:

  • Understanding exercise-induced pulmonary changes is crucial for athletes and individuals in high-altitude environments.
  • Normobaric hypoxia simulates high-altitude conditions without changes in barometric pressure.

Purpose of the Study:

  • To investigate acute alterations in pulmonary function and lung volumes during running in a simulated normobaric hypoxic environment.
  • To compare these changes with those observed during normoxic running.

Main Methods:

  • Eleven healthy men completed a 5-mile run under both normoxic and normobaric hypoxic conditions (simulated 2286m altitude).
  • Pulmonary function, lung volumes, cardiac output (impedance cardiography), and thoracic fluid shifts (impedance) were measured.

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  • Diffusing capacity for carbon monoxide (DLCO) and expiratory flow rates were assessed.

    • Main Results:

    • Both normoxic and hypoxic runs induced similar reductions in vital capacity (7%) and increases in residual volume (10%), with no change in total lung capacity.
    • No significant changes were observed in flow rates, closing volume/capacity, or thoracic impedance.
    • A fall in pulmonary blood flow occurred post-run, but diffusing capacity remained unaffected.

    Conclusions:

    • Lung volume changes after running in normobaric hypoxia are comparable to normoxic conditions and attributed to expiratory limitation.
    • The study did not find evidence supporting exercise-induced interstitial edema as a cause for these changes.
    • Hypoxic pulmonary vasoconstriction did not alter the pulmonary responses observed after equivalent normoxic exercise.