Related Experiment Video
Updated: Nov 18, 2025

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Cerebral venous thrombosis
Omri Cohen1,2,3, Samuela Pegoraro4, Walter Ageno4
1National Hemophilia Center, Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel-Hashomer, Israel - omricmd@gmail.com.
Insights
Cerebral venous thrombosis (CVT), a rare deep venous thrombosis (DVT), is an increasing cause of stroke in young adults. Early anticoagulation is crucial for management and survival.
Area of Science:
- Neurology
- Vascular Medicine
- Hematology
Background:
- Cerebral venous thrombosis (CVT) is an uncommon but significant cause of stroke, particularly in younger populations.
- Its incidence appears to be rising, with risk factors including those for DVT plus local factors like head trauma and infections.
- Variable clinical presentations often lead to diagnostic delays.
Purpose of the Study:
- To provide a comprehensive review of current knowledge on CVT.
- To discuss incidence, pathophysiology, risk factors, clinical presentation, diagnosis, and management.
- To summarize recent guidelines and data on direct oral anticoagulants (DOACs) for CVT.
Main Methods:
- This is a review article synthesizing existing literature and recent guidelines.
- It covers epidemiology, etiological factors, clinical manifestations, and diagnostic modalities.
- Management strategies, including anticoagulation and surgical interventions, are discussed.
Main Results:
- CVT diagnosis can be challenging due to its variable presentation.
- Early anticoagulation is vital and intracranial hemorrhage is not a contraindication.
- Decompressive surgery and endovascular treatments are options for severe cases.
Conclusions:
- Timely diagnosis and prompt anticoagulant therapy are essential for favorable outcomes in CVT.
- DOACs represent a significant advancement in CVT treatment.
- A multidisciplinary approach is often required for optimal patient management.
Abstract:
Cerebral venous thrombosis (CVT) is a rare form of deep venous thrombosis (DVT), yet a leading cause of stroke in young adults, with an incidence that seems to be increasing in recent years. Risk factors for CVT overlap with those of DVT in other locations, with the addition of local risk factors, such as infections, head trauma and neurosurgery. The clinical presentation is highly variable, hence the diagnosis of CVT may be delayed or overlooked. Early recognition and timely initiation of anticoagulant treatment are of essence, while decompressive surgery can be lifesaving for patients with impending trans-tentorial herniation. Concomitant intracranial hemorrhage is not a contraindication to anticoagulant treatment. Endovascular treatment may be suggested for selected patients who deteriorate despite anticoagulant treatment. In this review we will provide an extensive and contemporary discussion of the incidence, pathophysiology, risk factors, clinical presentation, neuroimaging and management of CVT, in accordance with recent guidelines. Additionally, we will summarize the latest data with regards to direct oral anticoagulants (DOACs) treatment in CVT.
Related Concept Videos
Venous Thrombosis I: Introduction
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis III: Interprofessional Care
Veins of Head and Neck
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
Cerebral Hemispheres
Venous Thrombosis IV: Nursing Management

