Cerebral venous thrombosis

Omri Cohen1,2,3, Samuela Pegoraro4, Walter Ageno4

  • 1National Hemophilia Center, Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel-Hashomer, Israel - omricmd@gmail.com.

Minerva Medica
|February 8, 2021
PubMed

Insights

Cerebral venous thrombosis (CVT), a rare deep venous thrombosis (DVT), is an increasing cause of stroke in young adults. Early anticoagulation is crucial for management and survival.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Hematology

Background:

  • Cerebral venous thrombosis (CVT) is an uncommon but significant cause of stroke, particularly in younger populations.
  • Its incidence appears to be rising, with risk factors including those for DVT plus local factors like head trauma and infections.
  • Variable clinical presentations often lead to diagnostic delays.

Purpose of the Study:

  • To provide a comprehensive review of current knowledge on CVT.
  • To discuss incidence, pathophysiology, risk factors, clinical presentation, diagnosis, and management.
  • To summarize recent guidelines and data on direct oral anticoagulants (DOACs) for CVT.

Main Methods:

  • This is a review article synthesizing existing literature and recent guidelines.
  • It covers epidemiology, etiological factors, clinical manifestations, and diagnostic modalities.
  • Management strategies, including anticoagulation and surgical interventions, are discussed.

Main Results:

  • CVT diagnosis can be challenging due to its variable presentation.
  • Early anticoagulation is vital and intracranial hemorrhage is not a contraindication.
  • Decompressive surgery and endovascular treatments are options for severe cases.

Conclusions:

  • Timely diagnosis and prompt anticoagulant therapy are essential for favorable outcomes in CVT.
  • DOACs represent a significant advancement in CVT treatment.
  • A multidisciplinary approach is often required for optimal patient management.

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