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5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue
S V Cannon1, A Cummings, G W Teebor
1Department of Pathology, New York University School of Medicine, New York, NY 10016.
Biochemical and Biophysical Research Communications
|March 30, 1988
Abstract:
The enzymatic release of 5-hydroxymethylcytosine from T2 bacteriophage DNA was effected by an extract of calf thymus. Like the previously described 5-hydroxymethyluracil DNA glycosylase, 5-hydroxymethylcytosine DNA glycosylase was not detectable in bacterial extracts. The phylogenetic distribution of these activities indicates that their primary function is the maintenance of methylcytosine residues in differentiated tissue.